2017-18 Catalog

Medical Laboratory Sciences and Public Health

Master of Science in Medical Laboratory Sciences

The Master of Science in Medical Laboratory Sciences offers students either a non-thesis track with two concentrations (Molecular Diagnostics or Laboratory Management) or a thesis track with a concentration in Molecular Diagnostics. All of the M.S. degree options are thirty-six credit hours.

Admission to either the thesis or non-thesis tracks of the M.S. in Medical Laboratory Sciences requires:

  • Approval of the Admissions Committee
  • Admission to the Graduate School
  • One of the following:
    • Professional certification in one of the following areas:
      • MLS/MT (ASCP)
      • HTL (ASCP)
      • CT (ASCP)
      • CG (ASCP)
      • ASCP Specialist certification including:
        • SM
        • SC
        • SH
        • SBB
    • Bachelor of Science in:
      • Biology
      • Biochemistry
      • Molecular Biology
      • Microbiology
      • Related Field1
1

With a minimum of 16 credit hours in biology (including microbiology, immunology, molecular biology), 16 credit hours in chemistry (including 8 hours in inorganic chemistry and 8 hours of organic chemistry or 4 hours organic chemistry and 4 hours biochemistry), approval of the Program Director and admission to the Graduate school.

Applications, deadlines and additional information may be found atwww.tarleton.edu/medicallab

Master of Science in Medical Laboratory Sciences

Required Courses
Molecular Diagnostics Emphasis - Thesis
Required courses (15 credit hours)
MDLS 5101CLS Literature review Seminar1
MDLS 5220Medical Genetics2
MDLS 5330Medical Biochemistry3
MDLS 5331Molecular and Cellular Pathology3
MDLS 5340Clinical and Anatomic Pathology3
MDLS 5398Statistical Methods Health Care Research3
Molecular Diagnostics - Thesis (21 credit hours)
MDLS 5221Immunopathology2
MDLS 5325Clinical Molecular Microbiology3
MDLS 5250Molecular Diagnostics Techniques I2
MDLS 5251Molecular Diagnostics Techniques II2
MDLS 5088Thesis1-6
MDLS 5099Practicum, Field Problem, or Internship1-3
MLS Elective 13
Total Hours36
Molecular Diagnostics Emphasis - Non Thesis
Required courses (15 credit hours)
MDLS 5101CLS Literature review Seminar1
MDLS 5220Medical Genetics2
MDLS 5330Medical Biochemistry3
MDLS 5331Molecular and Cellular Pathology3
MDLS 5340Clinical and Anatomic Pathology3
MDLS 5398Statistical Methods Health Care Research3
Molecular Diagnostics - Non-Thesis (21 credit hours)
MDLS 5221Immunopathology2
MDLS 5325Clinical Molecular Microbiology3
MDLS 5250Molecular Diagnostics Techniques I2
MDLS 5251Molecular Diagnostics Techniques II2
MDLS 5086Clinical Laboratory Science Problems1-3
MDLS 5099Practicum, Field Problem, or Internship1-3
MLS Elective 17
Total Hours36
Laboratory Management Emphasis - Non-Thesis
Required courses (15 credit hours)
MDLS 5101CLS Literature review Seminar1
MDLS 5220Medical Genetics2
MDLS 5330Medical Biochemistry3
MDLS 5331Molecular and Cellular Pathology3
MDLS 5340Clinical and Anatomic Pathology3
MDLS 5398Statistical Methods Health Care Research3
Laboratory Management - Non-Theses (21 credit hours)
BLAW 5303Healthcare Law3
ACCT 5300Foundations of Financial Systems3
MGMT 5300Foundations of Management3
MGMT 5311Managing Operations and Services3
MDLS 5206Laboratory Management2
MDLS 5272Clinical Laboratory Administration2
MDLS 5086Clinical Laboratory Science Problems1-3
MLS Elective 13
Total Hours36
1

 MLS approved electives include: MDLS 5101 (1), MDLS 5202 (2), MDLS 5204, MDLS 5206, MDLS 5174 (1), MDLS 5086 (1-3), MDLS 5090 (3), MDLS 5099 (1-3)

Graduates of Tarleton State University's Medical Laboratory Science Certificate program may substitute MDLS 5202 Molecular Diagnostics, MDLS 5204 Clinical Correlations and Capstone Review and MDLS 5206 Laboratory Management forMDLS 5340 Clinical and Anatomic Pathology and MLS Electives.

Both the thesis and non-thesis Molecular Diagnostics options require a three credit hour practicum, in which students gain exposure and practice molecular techniques

Courses

MDLS 5086. Clinical Laboratory Science Problems. 1-3 Credit Hours (Lecture: 1-3 Hours, Lab: 0 Hours).

Independent research under the supervision of an instructor. A formal report will be submitted to the instructor. A maximum of six hours may be taken.

MDLS 5088. Thesis. 1-6 Credit Hours (Lecture: 1-6 Hours, Lab: 0 Hours).

Scheduled when the student is ready to begin thesis. No credit until thesis is completed.

MDLS 5090. Special Topics. 1-3 Credit Hours (Lecture: 1-3 Hours, Lab: 0 Hours).

Study of selected topic(s) directly related to medical laboratory science. May be repeated once for credit as topic varies.

MDLS 5099. Practicum, Field Problem, or Internship. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 8-24 Hours).

Supervised professional activities in specialized laboratory settings. A maximum of six hours may be taken.

MDLS 5101. CLS Literature review Seminar. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Review of current literature topics in the medical laboratory sciences. Emphasis is placed on critique of methods, research design and value to the current body of knowledge. May be repeated for credit for a maximum of 6 credit hours.

MDLS 5110. Hematology for Cytogeneticist. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Study of the formation and function of the formed elements of the blood. Emphasis is placed on the pathogenesis of peripheral blood and bone marrow disorders including the correlation of cytogenetic abnormalities. Course Fee $30.

MDLS 5170. Clin Cytogenetics Lab Oper/Pra. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

This course is designed to acquaint students with the operations of a modern cytogenetics laboratory. Emphasis will be placed on problem-solving processes and strategies to resolve difficult cases. Issues related to the reimbursement and regulation are addressed. Course Fee $30.

MDLS 5174. Intro Lab Safety and Operations. 1 Credit Hour (Lecture: 1 Hour, Lab: 1 Hour).

Introduction to the theories and principles of instrument operation and safety practices commonly used in the clinical laboratory. Supervised learning experience in instrument operation and troubleshooting. Course fee $15.

MDLS 5202. Molecular Diagnostics. 2 Credit Hours (Lecture: 2 Hours, Lab: 1 Hour).

An overview of molecular mechanisms including replication, transcription, and translation. Emphasis is placed on the principles of molecular methods and their application in diagnosis of microbiologic, immunologic, genetic, endocrine, hematopoietic, and metabolic disease.

MDLS 5204. Clinical Correlations and Capstone Review. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Course employs an integrative approach to laboratory medicine with emphasis on the review of patient cases and appropriate utilization of laboratory tests in diagnosis and case management. A comprehensive review and assessment of the concepts in clinical laboratory medicine.

MDLS 5206. Laboratory Management. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Designed to acquaint students with the principles of operating a clinical laboratory. Emphasis is on personnel, financial, marketing, and general administrative management. Also, the student is introduced to writing instructional objectives, constructing evaluation instruments, and planning instructional strategies and establishing a professional development program. Ethical issues in laboratory medicine are also discussed.

MDLS 5220. Medical Genetics. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Study of human genetics including chromosome structure, principles of inheritance, anatomy and physiology of a gene, genetic expression and regulation, cytogenetics, immunogenetics, molecular genetics, with an emphasis on diagnostic testing for human genetic diseases and the genetic basis of cancer. Prerequisite Course: BIOL 3403 or MDLS 4148.

MDLS 5221. Immunopathology. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Principles of innate and adaptive immunity including antigen recognition, signal transduction, lymphocyte development and homeostasis of lymphocyte populations, cytokine effects, failure of host defense mechanisms such as autoimmunity, immunodeficiencies, immunoproliferative diseases, analysis of the immune response in intact and manipulated organisms, and tumor immunobiology, with emphasis on clinical induction, measurement and manipulation of the human immune response. Prerequisite Course: BIOL 3485 or MDLS 4166.

MDLS 5250. Molecular Diagnostics Techniques I. 2 Credit Hours (Lecture: 1 Hour, Lab: 5 Hours).

This course provides an introduction to the basic genetic techniques used in a clinical molecular genetics laboratory. Laboratory technique instruction, skill development and practice in isolation of DNA and RNA from clinical samples, preparation of nucleic acid probes, molecular hybridization techniques, amplification techniques and hybridization analysis will be addressed. Emphasis will be placed on laboratory design issues, prevention of product contamination, quality assurance and regulatory issues, safety, and interpretation and application of test results. Lab Fee $2.

MDLS 5251. Molecular Diagnostics Techniques II. 2 Credit Hours (Lecture: 1 Hour, Lab: 5 Hours).

This course provides a continuation of the basic genetic techniques covered in Molecular Diagnostics Techniques I, which may be used in a clinical molecular genetics laboratory. Laboratory technique instruction, skill development and practice in real-time PCR, reverse transcriptase PCR, nested PCR and single nucleotide polymorphism (SNP) detection will be emphasized. Emphasis will be placed on laboratory design issues, prevention of product contamination, quality assurance and regulatory issues, safety, and interpretation and application of test results. Lab Fee $2.

MDLS 5272. Clinical Laboratory Administration. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Principles and practices of administration of the clinical laboratory. Emphasis is placed on administrative issues unique to the clinical laboratory including coding, billing, reimbursement, government regulation, accreditation and information management processes. Prerequisite Course: MDLS 5206.

MDLS 5295. Clinical Cytogenetics Pract I. 2 Credit Hours (Lecture: 0 Hours, Lab: 13 Hours).

Under the supervision and instruction of a clinical instructor in a hospital or reference laboratory setting, the student will have the opportunity to expand their knowledge of principles and techniques involved in the practice of cytogenetics that were introduced in the diadactic portion of the curriculum. the student will gain experience in procedures related to karyotyping with an emphasis on peripheral blood specimens. Clinical correlations of the chromosomal findings are emphasized. Field assignment fee $75. Grading in this course is satisfactory or unsatisfactory.

MDLS 5296. Clinical Cytogenetics Pract II. 2 Credit Hours (Lecture: 0 Hours, Lab: 13 Hours).

Under the supervision and instruction of a clinical instructor in a hospital or reference laboratory setting, the student will have the opportunity to expand their knowledge of principles and techniques involved in the practice of cytogenetics that were introduced in the diadactic portion of the curriculum. The student will gain experience in procedures related to karyotyping with an emphasis on amniotic fluid, chorionic villi samples,bone marrow and solid tumor specimens. Clinical correlations of the chromosomal findings are emphasized. Field assignment fee $75. Grading in this course is satisfactory or unsatisfactory.

MDLS 5297. Clinical Cytogenetics Pract III. 2 Credit Hours (Lecture: 0 Hours, Lab: 13 Hours).

Under the supervision and instruction of a clinical instructor in a hospital or reference laboratory setting, the student will have the opportunity to expand their knowledge of principles and techniques involved in the practice of cytogenetics that were introduced in the diadactic portion of the curriculum. The student will gain experience in procedures related to karotyping, FISH and molecular techniques. Clinical correlations of the chromosomal findings are emphasized. Field assignment fee $75. Grading in this course is satisfactory or unsatisfactory.

MDLS 5325. Clinical Molecular Microbiology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Studies of the genetics and physiology of microbes, including fundamental processes of gene regulation, genome structure, and protein synthesis and processing. Emphasis is placed on the clinical molecular identification of bacteria, viral, fungal and parasitic organisms including real-time PCR techniques, quality assurance practices, and interpretation of results in a clinical setting.

MDLS 5330. Medical Biochemistry. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

A review of the major biochemical processes in the human body, their physiology role and their relationship to human disease. Emphasis will be placed upon emerging diagnostic testing and clinical correlations in the areas of endocrinology, tumor biology, lipoprotine structure and function, diabetes case management, protein structure and function, and toxicology. Prerequisite Course: BIOL 4374 or CHEM 4374 or MDLS 4278.

MDLS 5331. Molecular and Cellular Pathology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

A study of the molecular and cellular aspects of human disease. Emphasis will be placed on microarrays and other emerging diagnostic testing as applied to the regulation of the eukaryotic cell cycle, signal transduction pathways, molecular mechanisms, receptor/membrane function and their relationship to tumor biology, endocrine dysfunction, dyslipidemia and other pathophysiologic conditions. Prerequisite Course(s): BIOL 5309 or MDLS 5202.

MDLS 5340. Clinical and Anatomic Pathology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Clinical and anatomic pathology is focused on the development of pathophysiologic mechanisms underlying human disease. Students are introduced to basic etiologies and pathogenesis that underlie all diseases. More detailed discussions of pathologic mechanisms including structural lesions (morphology) and functional consequences (clinical presentation) will be discussed within specific diseases of organ systems. Applications of the clinical laboratory in disease diagnosis and management will also be included.

MDLS 5355. Clinical Cytogenetics Techniques I. 3 Credit Hours (Lecture: 1 Hour, Lab: 6 Hours).

This course introduces all aspects of the modern cytogenetics laboratory including karotyping and probe based assays including fluoresence in-situ hybridization (FISH). Quality assurance aspects of quality laboratory practices are introduced as well as regulatory issues. Course Fee $30 Lab Fee $30.

MDLS 5356. Clinical Cytogenetics Techniques II. 3 Credit Hours (Lecture: 1 Hour, Lab: 6 Hours).

This course is a continuation of MLS 5355 and provides more advanced practice in all aspects of the modern cytogenetics laboratory including karotyping and fluoresence in-situ hybridization (FISH). Quality assurance aspects of quality laboratory practices are emphasized as well as regulatory issues. Lab fee $2.

MDLS 5398. Statistical Methods Health Care Research. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Practical applications of general principles of descriptive and inferential statistics used in health care research. Skill development in use of statistical software as a tool to analyze health data available from national databases. Emphasis will be placed on the interpretation and communication of research results. Course Fee $50.

MDLS 5412. Clinical Cytogenetics. 4 Credit Hours (Lecture: 4 Hours, Lab: 0 Hours).

This covers the history of cytogenetics, mechanisms of structural abnormalities, clinical correlation of autosomal and sex chromosome anomalies, cytogenetic syndromes, inheritance patterns and cancer genetics with a focus on correlation between the diagnosis and treatment of diseases associated with genetic abnormalities. Course Fee $30.

Tarleton State University
Department of Medical Laboratory Sciences and Public Health
1501 Enderly Place
Fort Worth, Texas 76104
817-926-1101
817-922-8103
www.tarleton.edu/medicallab

Sally Lewis, Ph.D., MLS (ASCP), MB; Head
On-Campus: 7222 Off-Campus: (817) 926-1101
slewis@tarleton.edu

Sara Taylor, Ph.D., MLS (ASCP), MB
MS-MLS Advisor
On-Campus: 7226 Off-Campus: (817)-926-1101
sataylor@tarleton.edu