Medical Laboratory Sciences

MDLS 1100. Transitioning to University Studies in Health Professions. 1 Credit Hour (Lecture: 1 Hour, Lab: 1 Hour).

Practical study designed to prepare the student for university life, and in the development of skills for academic success, promote personal growth and responsibility, and encourage active involvement in the learning process from an individual college perspective. Also included will be the development of skills to promote physical and mental health.

MDLS 1111. Surv Allied Health Prof. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Course description is needed.

MDLS 4086. Clinical Laboratory Science Problems. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 1-3 Hours).

A course open by invitation to capable Clinical Laboratory Science students who wish to pursue a selected problem study. Students are permitted and encouraged to work independently under the guidance of an instructor. May be repeated for credit, subject to the approval of the department head. Lab fee: $2.

MDLS 4091. Integrated Clinical Laboratory Practice and Research. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 5-15 Hours). [WI]

An integrated clinical laboratory course designed to introduce the concepts of specimen tracking and processing using a laboratory information system, test result utilization, utilization review, and clinical research. Emphasis will be placed on workload organization; quality control evaluation accuracy; consistency; validity of results generated; and appropriate reporting of results. Lab fee: $2.

MDLS 4092. Clinical Laboratory Practicum I. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in hematology, hemostasis, and body fluid analysis. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4093. Clinical Laboratory Practicum II. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 8-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in medical microbiology and parasitology. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4094. Clinical Laboratory Practicum III. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 8-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in immunology, serology, and blood banking. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4095. Clinical Laboratory Practicum IV. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 8-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work and solving problems in clinical chemistry, toxicology, and molecular pathology. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4096. Advanced Clinical Practicum. 1-8 Credit Hours (Lecture: 0 Hours, Lab: 3-24 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in the clinical laboratory. Emphasis is given to high complexity testing. Grading in this course is satisfactory/unsatisfactory.

MDLS 4104. Clinical Correlations and Capstone Review Specialty. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

This course employs an integrative approach to laboratory medicine with emphasis on the review of patient cases and appropriate utilization of laboratory tests in diagnosis and case management. A comprehensive review and assessment of the concepts in a specialty area of medical laboratory medicine. Prerequisite: Acceptance to Public Health Microbiology Categorical Certification program.

MDLS 4115. Urinalysis and Body Fluids Laboratory. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised learning experiences using microscopic, chemical, and automated techniques in analysis of urine, synovial, seminal, cerebrospinal, serous, and amniotic fluid.

MDLS 4125. Hematology I Laboratory. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experiences with emphasis placed on the enumeration, morphology and staining characteristics of normal blood cells as well as analytes to evaluate coagulation and fibrinolysis. Manual and automated techniques will be used. Emphasis will be placed on specimen collection, processing, and generation and evaluation of diagnostic data.

MDLS 4127. Hematology II Laboratory. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experiences with emphasis placed on the enumeration, morphology, and staining characteristics of abnormal blood cells. Emphasis will be placed on specimen processing and generation and evaluation of diagnostic data. Prerequisite: Co-Requisite: MDLS 4226 or approval of department head Lab fee: $2.

MDLS 4128. Hemostasis. 1 Credit Hour (Lecture: 1 Hour, Lab: 2 Hours).

Discussion and comparison of the hemostatic coagulation and fibrinolytic systems with emphasis on normal and abnormal physiology. Supervised learning experiences with emphasis on analytes to evaluate coagulation and fibrinolysis. Manual and automated techniques will be discussed and used.

MDLS 4135. Medical Microbiology I Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experience with emphasis on isolation, staining, culture, and differential biochemical characteristics of pathogenic microorganisms and human parasites. Specimen collection, processing and criteria for rejection will also be addressed. Emphasis will be placed on deriving diagnostic laboratory results and evaluation of those results.

MDLS 4137. Medical Microbiology II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experience with emphasis on staining, isolation, identification, and antimicrobial susceptibility testing of microorganisms isolated from clinical specimens. Emphasis is also placed on specimen processing and generation and evaluation of diagnostic data. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 4336. Lab fee: $2.

MDLS 4148. Introduction to Medical Genetics. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

An introduction to the concepts of gene structure and inheritance patterns. Emphasis will be placed on the types of inheritance patterns associated with different disease conditions in which clinical diagnostics plays a valuable role in disease diagnosis or patient counseling.

MDLS 4149. Immunohematology Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experiences related to blood grouping and typing and compatibility testing, antibody detection and identification, incompatibility and transfusion reaction resolution; component processing and storage; and selection for therapy. Emphasis is placed on specimen processing, laboratory techniques, and generation and evaluation of diagnostic data.

MDLS 4169. Immunology and Serology Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised learning experience with emphasis on the detection, identification, and characterization of antigens and antibodies involved in autoimmune disease and infectious etiology using serologic techniques. Also emphasis on cells involved in cellular immunity using immunologic techniques, specimen processing and generation and evaluation of diagnostic data.

MDLS 4174. Introduction to Laboratory Safety and Instrumentation. 1 Credit Hour (Lecture: 1 Hour, Lab: 2 Hours).

Introduction to the theories and principles of instrument operation and safety practices commonly used in the clinical laboratory. Supervised learning experience in instrument operation and troubleshooting.

MDLS 4175. Advanced Laboratory Automation, Statistics, and Quality Assurance Concepts. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Discussion and comparison of operating principles of automated analyzers, complex laboratory techniques, statistical methods and quality assurance concepts applicable to the clinical laboratory. Supervised learning experience in instrument operation, troubleshooting, electrophoresis and chromatography. Application of statistics to quality assurance and evaluation of laboratory results will be discussed.

MDLS 4177. Clinical Chemistry I Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours). [WI]

Supervised learning experiences with emphasis on manual, semi-automated, and automated procedures for assaying electrolytes, blood gases, carbohydrates, lipids, proteins, and drugs. Emphasis is placed on specimen processing and generation and evaluation of diagnostic data. Lab fee: $2.

MDLS 4179. Clinical Chemistry II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised learning experiences with emphasis on manual, semi-automated, and automated procedures for assaying metabolites, drugs, enzymes, hormones, and tumor markers. Emphasis is placed on specimen selection, processing, analyses, and evaluation of diagnostic data. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 4378. Lab fee: $2.

MDLS 4202. Molecular Diagnostics. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

An overview of molecular mechanisms including replication, transcription, and translation. Emphasis is placed on the principles of molecular methods and their application in diagnosis of microbiologic, immunologic, genetic, endocrine, hematopoietic, and metabolic disease.

MDLS 4204. Clinical Correlations and Capstone Review Speciality. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

This course employs an integrative approach to laboratory medicine with emphasis on the review of patient cases and appropriate utilization of laboratory tests in diagnosis and case management. A comprehensive review and assessment of the concepts in a specialty area of medical laboratory medicine.

MDLS 4214. Urinalysis and Body Fluids Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion in renal physiology, relationship to renal and other systemic diseases, physiologic function and pathophysiology of synovial, seminal, cerebrospinal, serous, and amniotic fluid.

MDLS 4226. Hematology II Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Studies on the formation and identification of abnormal cellular blood elements are discussed. Emphasis is placed on abnormal physiology and hematologic manifestations of disease. Prerequisite: MDLS 4224 or approval of department head. Co-Requisite: MDLS 4127 or approval of department head.

MDLS 4274. Introduction to Lab Safety and Operations. 2 Credit Hours (Lecture: 2 Hours, Lab: 1 Hour).

Introduction to the theories and principles of instrument operation and safety practices commonly used in the clinical laboratory. Supervised learning experience in instrument operation and troubleshooting and the use of computers in the scientific and medical fields.

MDLS 4276. Clinical Chemistry I Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

An introduction to the theories and principles of diagnostic methods used to measure common analytes involved in water and acid base balance, mineral and metabolic homeostasis in serum and other body fluids. Normal physiology and biochemical manifestation of disease are emphasized. Co-requisite : MDLS 4177.

MDLS 4292. Clinical Laboratory Practicum I. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in hematology, hemostasis, and body fluid analysis. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 4293. Clinical Laboratory Practicum II. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in medical microbiology and parasitology. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 4294. Clinical Laboratory Practicum III. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in immunology, serology, and blood banking. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 4295. Clinical Laboratory Practicum IV. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in clinical chemistry, toxicology, and molecular pathology. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 4324. Hematology I Lecture. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion of the formation, function, physiology, and identification of normal blood cellular elements in all ages and hemostatic coagulation and fibrinolytic systems with emphasis on normal and abnormal physiology.

MDLS 4334. Medical Microbiology I Lecture. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion of pathology, growth characteristics, morphology, physiology, and identification criteria of human pathogenic microorganisms, normal flora and parasites causing disease in humans. Opportunistic parasites in the immunocompromised host will also be addressed.

MDLS 4336. Medical Microbiology II Lecture. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion of advanced microbiological concepts including anaerobic bacteria, mycobacterium, antimicrobial susceptibility, mycology, virology, and infections by organ system. Emphasis is on epidemiology, pathogenesis, source of isolation, and conventional and molecular methods of diagnosis of human pathogenic organisms. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 4137.

MDLS 4360. Introduction to Clinical Immunology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion of immunological mechanisms fundamental to resistance to disease. Emphasis is placed on the basic humoral and cellular immune response and resistance to microbial disease with particular attention to medical laboratory assay principles.

MDLS 4364. Immunology and Serology Lecture. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion of immunological mechanisms fundamentals to resistance to disease including basic humoral and cellular immune responses, mechanisms and pathogenesis involved in microbial, autoimmune, allergic, and immunodeficient disease.

MDLS 4378. Clinical Chemistry II Lecture. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion and comparison of diagnostic methods employed in the clinical chemistry laboratory. Emphasis is placed on diagnostic metabolites, enzymology, endocrinology,tumor markers, and advanced methods and technologies. Normal physiology and biochemical manifestations of disease are discussed. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 4179.

MDLS 4391. Integrated Clinical Laboratory Practice and Research. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 5-15 Hours). [WI]

An integrated clinical laboratory course designed to introduce the concepts of specimen tracking and processing using a laboratory information system, test result utilization, utilization review, and clinical research. Emphasis will be placed on workload organization; quality control evaluation accuracy; consistency; validity of results generated; and appropriate reporting of results. Lab fee: $2.

MDLS 4444. Immunohematology Lecture. 4 Credit Hours (Lecture: 4 Hours, Lab: 0 Hours).

Discussion of the principles of immunohematology in relation to blood grouping, typing, compatibility testing, and antibody detection and identification, transfusion and transplant medicine, donor processing, and component preparation and storage.

MDLS 4592. Clinical Laboratory Practicum I. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in hematology, hemostasis, and body fluid analysis. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4593. Clinical Laboratory Practicum II. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 8-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in medical microbiology and parasitology. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4594. Clinical Laboratory Practicum III. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 8-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in immunology, serology, and blood banking. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4595. Clinical Laboratory Practicum IV. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 8-40 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work and solving problems in clinical chemistry, toxicology, and molecular pathology. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 4896. Advanced Clinical Practicum. 1-8 Credit Hours (Lecture: 0 Hours, Lab: 3-24 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in the clinical laboratory. Emphasis is given to high complexity testing. Grading in this course is satisfactory/unsatisfactory.

MDLS 5086. Clinical Laboratory Science Problems. 1-3 Credit Hours (Lecture: 1-3 Hours, Lab: 0 Hours).

Independent research under the supervision of an instructor. A formal report will be submitted to the instructor. A maximum of six hours may be taken.

MDLS 5088. Thesis. 1-6 Credit Hours (Lecture: 1-6 Hours, Lab: 0 Hours).

Scheduled when the student is ready to begin thesis. No credit until thesis is completed.

MDLS 5090. Special Topics. 1-3 Credit Hours (Lecture: 1-3 Hours, Lab: 0 Hours).

Study of selected topic(s) directly related to medical laboratory science. May be repeated once for credit as topic varies.

MDLS 5091. Integrated Clinical Laboratory Science and Research. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 5 Hours).

An integrated clinical laboratory course designed to introduce the concepts of specimen tracking and processing using a laboratory information system, test result utilization, utilization review, and clinical research. Emphasis will be placed on workload organization; quality control evaluation accuracy; consistency; validity of results generated; and appropriate reporting of high complexity results.

MDLS 5092. Clinical Laboratory Practicum I. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in hematology, hemostasis, and body fluid analysis. Emphasis is placed on the analysis of high complexity quality assurance data and application of laboratory information systems and automation. Grading in this course is pass/fail.

MDLS 5093. Clinical Laboratory Practicum II. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving high complexity problems in medical microbiology and parasitology. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 5094. Clinical Laboratory Practicum III. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in immunology, serology, and blood banking. Emphasis is placed on the analysis of high complexity quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 5095. Clinical Laboratory Practicum IV. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work and solving problems in clinical chemistry, toxicology, and molecular pathology. Emphasis is placed on the analysis of high complexity quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 5099. Practicum, Field Problem, or Internship. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 8-24 Hours).

Supervised professional activities in specialized laboratory settings. A maximum of six hours may be taken.

MDLS 5101. CLS Literature review Seminar. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Review of current literature topics in the medical laboratory sciences. Emphasis is placed on critique of methods, research design and value to the current body of knowledge. May be repeated for credit for a maximum of 6 credit hours.

MDLS 5127. Hematology II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experiences with emphasis placed on the enumeration, morphology, and staining characteristics of abnormal blood cells. Emphasis will be placed on specimen processing and generation and evaluation of diagnostic data and additional analysis and troubleshooting skills. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5226.

MDLS 5137. Medical Microbiology II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experience with emphasis on staining, isolation, identification, and antimicrobial susceptibility testing of microorganisms isolated from clinical specimens. Emphasis is also placed on specimen processing and generation and evaluation of diagnostic data and additional analysis and troubleshooting skills. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5336.

MDLS 5149. Immunohematology Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experiences related to blood grouping and typing and compatibility testing, antibody detection and identification, incompatibility and transfusion reaction resolution; component processing and storage; and selection for therapy. Emphasis is placed on specimen processing, laboratory techniques, and generation and evaluation of diagnostic data.

MDLS 5174. Intro Lab Safety and Operations. 1 Credit Hour (Lecture: 1 Hour, Lab: 1 Hour).

Introduction to the theories and principles of instrument operation and safety practices commonly used in the clinical laboratory. Supervised learning experience in instrument operation and troubleshooting.

MDLS 5179. Clinical Chemistry II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised learning experiences with emphasis on manual, semi-automated, and automated procedures for assaying metabolites, drugs, enzymes, hormones, and tumor markers. Emphasis is placed on specimen selection, processing, analyses, and evaluation of diagnostic data and on high complexity analysis and troubleshooting skills. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5378.

MDLS 5202. Molecular Diagnostics. 2 Credit Hours (Lecture: 2 Hours, Lab: 1 Hour).

An overview of molecular mechanisms including replication, transcription, and translation. Emphasis is placed on the principles of molecular methods and their application in diagnosis of microbiologic, immunologic, genetic, endocrine, hematopoietic, and metabolic disease.

MDLS 5204. Clinical Correlations and Capstone Review. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Course employs an integrative approach to laboratory medicine with emphasis on the review of patient cases and appropriate utilization of laboratory tests in diagnosis and case management. A comprehensive review and assessment of the concepts in clinical laboratory medicine.

MDLS 5206. Laboratory Management. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Designed to acquaint students with the principles of operating a clinical laboratory. Emphasis is on personnel, financial, marketing, and general administrative management. Also, the student is introduced to writing instructional objectives, constructing evaluation instruments, and planning instructional strategies and establishing a professional development program. Ethical issues in laboratory medicine are also discussed.

MDLS 5220. Medical Genetics. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Study of human genetics including chromosome structure, principles of inheritance, anatomy and physiology of a gene, genetic expression and regulation, cytogenetics, immunogenetics, molecular genetics, with an emphasis on diagnostic testing for human genetic diseases and the genetic basis of cancer. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program.

MDLS 5221. Immunopathology. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Principles of innate and adaptive immunity including antigen recognition, signal transduction, lymphocyte development and homeostasis of lymphocyte populations, cytokine effects, failure of host defense mechanisms such as autoimmunity, immunodeficiencies, immunoproliferative diseases, analysis of the immune response in intact and manipulated organisms, and tumor immunobiology, with emphasis on clinical induction, measurement and manipulation of the human immune response. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program.

MDLS 5226. Hematology II Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Studies on the formation and identification of abnormal cellular blood elements are discussed. Emphasis is placed on abnormal physiology and hematologic manifestations of disease and high complexity analysis and troubleshooting. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-Requisite Course: MDLS 5127 or approval of department head.

MDLS 5244. Applications in Molecular Diagnostics I. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion of the theory and applications of molecular testing in microbiology, immunology, and pharmacogenomics. Methods discussed to include quantitative analysis, qualitative analysis, and methods of genotypic characterization.

MDLS 5245. Applications in Molecular Diagnostics II. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion of the theory and applications of molecular testing in oncology and genetics. Topics to include diagnosis of leukemia/lymphomas, solid tumors, hereditary cancer syndromes, and other genetic disorders.

MDLS 5272. Clinical Laboratory Administration. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Principles and practices of administration of the clinical laboratory. Emphasis is placed on administrative issues unique to the clinical laboratory including coding, billing, reimbursement, government regulation, accreditation and information management processes. Prerequisite: MDLS 5206.

MDLS 5292. Clinical Laboratory Practicum I. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in hematology, hemostasis, and body fluid analysis. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 5293. Clinical Laboratory Practicum II. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in medical microbiology and parasitology. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 5294. Clinical Laboratory Practicum III. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in immunology, serology, and blood banking. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 5295. Clinical Laboratory Practicum IV. 2 Credit Hours (Lecture: 0 Hours, Lab: 5-40 Hours).

Structured clinical experience directed toward developing laboratory skills, organizing work, and solving problems in clinical chemistry, toxicology, and molecular pathology. Emphasis is placed on the analysis of quality assurance data and the application of laboratory information systems and automation. Grading in this course is Pass/Fail.

MDLS 5296. Clinical Cytogenetics Pract II. 2 Credit Hours (Lecture: 0 Hours, Lab: 13 Hours).

Under the supervision and instruction of a clinical instructor in a hospital or reference laboratory setting, the student will have the opportunity to expand their knowledge of principles and techniques involved in the practice of cytogenetics that were introduced in the diadactic portion of the curriculum. The student will gain experience in procedures related to karyotyping with an emphasis on amniotic fluid, chorionic villi samples,bone marrow and solid tumor specimens. Clinical correlations of the chromosomal findings are emphasized. Field assignment fee $75. Grading in this course is satisfactory or unsatisfactory.

MDLS 5298. Statistical Methods for Healthcare Research. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Practical applications of general principles of descriptive and inferential statistics used in health care research. Skill development in use of statistical software as a tool to analyze health data available from national databases. Emphasis will be placed on the interpretation and communication of research results.

MDLS 5325. Clinical Molecular Microbiology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Studies of the genetics and physiology of microbes, including fundamental processes of gene regulation, genome structure, and protein synthesis and processing. Emphasis is placed on the clinical molecular identification of bacteria, viral, fungal and parasitic organisms including real-time PCR techniques, quality assurance practices, and interpretation of results in a clinical setting.

MDLS 5330. Medical Biochemistry. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

A review of the major biochemical processes in the human body, their physiology role and their relationship to human disease. Emphasis will be placed upon emerging diagnostic testing and clinical correlations in the areas of endocrinology, tumor biology, lipoprotine structure and function, diabetes case management, protein structure and function, and toxicology. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program.

MDLS 5331. Molecular and Cellular Pathology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

A study of the molecular and cellular aspects of human disease. Emphasis will be placed on microarrays and other emerging diagnostic testing as applied to the regulation of the eukaryotic cell cycle, signal transduction pathways, molecular mechanisms, receptor/membrane function and their relationship to tumor biology, endocrine dysfunction, dyslipidemia and other pathophysiologic conditions. Prerequisite: BIOL 5309 or MDLS 5202.

MDLS 5336. Medical Microbiology II Lecture. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion of advanced microbiological concepts including anaerobic bacteria, mycobacterium, antimicrobial susceptibility, mycology, virology, and infections by organ system. Emphasis is on epidemiology, pathogenesis, source of isolation, and conventional and molecular methods of diagnosis of human pathogenic organisms. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5137.

MDLS 5340. Clinical and Anatomic Pathology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Clinical and anatomic pathology is focused on the development of pathophysiologic mechanisms underlying human disease. Students are introduced to basic etiologies and pathogenesis that underlie all diseases. More detailed discussions of pathologic mechanisms including structural lesions (morphology) and functional consequences (clinical presentation) will be discussed within specific diseases of organ systems. Applications of the clinical laboratory in disease diagnosis and management will also be included.

MDLS 5378. Clinical Chemistry II Lecture. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Discussion and comparison of diagnostic methods employed in the clinical chemistry laboratory. Emphasis is placed on diagnostic metabolites, enzymology, endocrinology, and tumor markers. Normal physiology and biochemical manifestations of disease are discussed. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5179.

MDLS 5398. Statistical Methods Health Care Research. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Practical applications of general principles of descriptive and inferential statistics used in health care research. Skill development in use of statistical software as a tool to analyze health data available from national databases. Emphasis will be placed on the interpretation and communication of research results.

MDLS 5444. Immunohematology Lecture. 4 Credit Hours (Lecture: 4 Hours, Lab: 0 Hours).

Discussion of the principles of immunohematology in relation to blood grouping, typing, compatibility testing, and antibody detection and identification, transfusion and transplant medicine, donor processing, and component preparation and storage.

MDLS 5450. Molecular Diagnostics Techniques I. 4 Credit Hours (Lecture: 1 Hour, Lab: 9 Hours).

This course provides an introduction to the basic genetic techniques used in a clinical molecular genetics laboratory. Laboratory technique instruction, skill development and practice in isolation of DNA and RNA from clinical samples, preparation of nucleic acid probes, molecular hybridization techniques, amplification techniques and hybridization analysis will be addressed. Emphasis will be placed on laboratory design issues, prevention of product contamination, quality assurance and regulatory issues, safety, and interpretation and application of test results.

MDLS 5451. Molecular Diagnostics Techniques II. 4 Credit Hours (Lecture: 1 Hour, Lab: 9 Hours).

This course provides a continuation of the basic genetic techniques covered in Molecular Diagnostics Techniques I, which may be used in a clinical molecular genetics laboratory. Laboratory technique instruction, skill development and practice in real-time PCR, reverse transcriptase PCR, nested PCR and single nucleotide polymorphism (SNP) detection will be emphasized. Emphasis will be placed on laboratory design issues, prevention of product contamination, quality assurance and regulatory issues, safety, and interpretation and application of test results. Prerequisite: MDLS 5450.