Graduate Medical Laboratory Sciences Courses

MDLS 5086. Clinical Laboratory Science Problems. 1-3 Credit Hours (Lecture: 1-3 Hours, Lab: 0 Hours).

Independent research under the supervision of an instructor. A formal report will be submitted to the instructor. A maximum of six hours may be taken.

MDLS 5088. Thesis. 1-6 Credit Hours (Lecture: 1-6 Hours, Lab: 0 Hours).

Scheduled when the student is ready to begin thesis. No credit until thesis is completed.

MDLS 5090. Special Topics. 1-3 Credit Hours (Lecture: 1-3 Hours, Lab: 0 Hours).

Study of selected topic(s) directly related to medical laboratory science. May be repeated once for credit as topic varies.

MDLS 5091. Integrated Clinical Laboratory Science and Research. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 5 Hours).

An integrated clinical laboratory course designed to introduce the concepts of specimen tracking and processing using a laboratory information system, test result utilization, utilization review, and clinical research. Emphasis will be placed on workload organization; quality control evaluation accuracy; consistency; validity of results generated; and appropriate reporting of high complexity results.

MDLS 5092. Clinical Laboratory Practicum I. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in hematology, hemostasis, and body fluid analysis. Emphasis is placed on the analysis of high complexity quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 5093. Clinical Laboratory Practicum II. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving high complexity problems in medical microbiology and parasitology. Emphasis is placed on the analysis of quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 5094. Clinical Laboratory Practicum III. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work, and solving problems in immunology, serology, and blood banking. Emphasis is placed on the analysis of high complexity quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 5095. Clinical Laboratory Practicum IV. 1-5 Credit Hours (Lecture: 0 Hours, Lab: 16 Hours).

Structured clinical experience directed toward development of laboratory skills, organizing work and solving problems in clinical chemistry, toxicology, and molecular pathology. Emphasis is placed on the analysis of high complexity quality assurance data and application of laboratory information systems and automation. Grading in this course is satisfactory/unsatisfactory.

MDLS 5099. Practicum, Field Problem, or Internship. 1-3 Credit Hours (Lecture: 0 Hours, Lab: 8-24 Hours).

Supervised professional activities in specialized laboratory settings. A maximum of six hours may be taken.

MDLS 5101. CLS Literature review Seminar. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Review of current literature topics in the medical laboratory sciences. Emphasis is placed on critique of methods, research design and value to the current body of knowledge. May be repeated for credit for a maximum of 6 credit hours.

MDLS 5110. Hematology for Cytogeneticist. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Study of the formation and function of the formed elements of the blood. Emphasis is placed on the pathogenesis of peripheral blood and bone marrow disorders including the correlation of cytogenetic abnormalities. Course Fee $30.

MDLS 5116. Body Fluids Analysis. 1 Credit Hour (Lecture: 1 Hour, Lab: 1 Hour).

Advanced concepts related to the biochemical and cellular analysis of body fluids. Includes normal physiologic function and pathophysiology of synovial, semenal, cerebrospinal, serous, and amniotic fluid. Emphasis on additional analysis and troubleshooting skills.

MDLS 5127. Hematology II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 5 Hours).

Supervised experiences with emphasis placed on the enumeration, morphology, and staining characteristics of abnormal blood cells. Emphasis will be placed on specimen processing and generation and evaluation of diagnostic data and additional analysis and troubleshooting skills. Prerequisites: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5226.

MDLS 5137. Medical Microbiology II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 5 Hours).

Supervised experience with emphasis on staining, isolation, identification, and antimicrobial susceptibility testing of microorganisms isolated from clinical specimens. Emphasis is also placed on specimen processing and generation and evaluation of diagnostic data and additional analysis and troubleshooting skills. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5236.

MDLS 5138. Medical Mycology and Virology. 1 Credit Hour (Lecture: 1 Hour, Lab: 1 Hour).

Discussion of the epidemiology and pathogenesis of fungi and viruses implicated in human disease. Emphasis will be placed upon diagnostic tools used in the clinical laboratory to isolate, culture, and identify these microorganisms and additional analysis and troubleshooting skills.

MDLS 5147. Immunohematology II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 4 Hours).

Supervised experiences related to antibody detection and identification, incompatibility and transfusion reaction resolution; component processing and storage; and selection for therapy. Emphasis is placed on specimen processing, laboratory techniques, and generation and evaluation of diagnostic data and additional analysis and troubleshooting skills. Prerequisites: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5246.

MDLS 5166. Immunology and Serology II Lecture. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

Discussion of immunologic mechanisms and pathogenesis involved in autoimmune, allergic, and immunodeficient diseases. Emphasis on analysis and troubleshooting.

MDLS 5167. Immunology and Serology II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 3 Hours).

Supervised learning experience with emphasis on the detection, identification, and characterization of antigens and antibodies involved in autoimmune disease. Also emphasis on cells involved in cellular immunity using immunologic techniques. Emphasis is placed on specimen processing and generation and evaluation of diagnostic data and high complexity analysis and troubleshooting skills. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5166.

MDLS 5170. Clin Cytogenetics Lab Oper/Pra. 1 Credit Hour (Lecture: 1 Hour, Lab: 0 Hours).

This course is designed to acquaint students with the operations of a modern cytogenetics laboratory. Emphasis will be placed on problem-solving processes and strategies to resolve difficult cases. Issues related to the reimbursement and regulation are addressed. Course Fee $30.

MDLS 5174. Intro Lab Safety and Operations. 1 Credit Hour (Lecture: 1 Hour, Lab: 1 Hour).

Introduction to the theories and principles of instrument operation and safety practices commonly used in the clinical laboratory. Supervised learning experience in instrument operation and troubleshooting. Course fee $15.

MDLS 5179. Clinical Chemistry II Lab. 1 Credit Hour (Lecture: 0 Hours, Lab: 5 Hours).

Supervised learning experiences with emphasis on manual, semi-automated, and automated procedures for assaying metabolites, drugs, enzymes, hormones, and tumor markers. Emphasis is placed on specimen selection, processing, analyses, and evaluation of diagnostic data and on high complexity analysis and troubleshooting skills. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-requisite MDLS 5278.

MDLS 5202. Molecular Diagnostics. 2 Credit Hours (Lecture: 2 Hours, Lab: 1 Hour).

An overview of molecular mechanisms including replication, transcription, and translation. Emphasis is placed on the principles of molecular methods and their application in diagnosis of microbiologic, immunologic, genetic, endocrine, hematopoietic, and metabolic disease.

MDLS 5204. Clinical Correlations and Capstone Review. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Course employs an integrative approach to laboratory medicine with emphasis on the review of patient cases and appropriate utilization of laboratory tests in diagnosis and case management. A comprehensive review and assessment of the concepts in clinical laboratory medicine.

MDLS 5206. Laboratory Management. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Designed to acquaint students with the principles of operating a clinical laboratory. Emphasis is on personnel, financial, marketing, and general administrative management. Also, the student is introduced to writing instructional objectives, constructing evaluation instruments, and planning instructional strategies and establishing a professional development program. Ethical issues in laboratory medicine are also discussed.

MDLS 5220. Medical Genetics. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Study of human genetics including chromosome structure, principles of inheritance, anatomy and physiology of a gene, genetic expression and regulation, cytogenetics, immunogenetics, molecular genetics, with an emphasis on diagnostic testing for human genetic diseases and the genetic basis of cancer. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program.

MDLS 5221. Immunopathology. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Principles of innate and adaptive immunity including antigen recognition, signal transduction, lymphocyte development and homeostasis of lymphocyte populations, cytokine effects, failure of host defense mechanisms such as autoimmunity, immunodeficiencies, immunoproliferative diseases, analysis of the immune response in intact and manipulated organisms, and tumor immunobiology, with emphasis on clinical induction, measurement and manipulation of the human immune response. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program.

MDLS 5226. Hematology II Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Studies on the formation and identification of abnormal cellular blood elements are discussed. Emphasis is placed on abnormal physiology and hematologic manifestations of disease and high complexity analysis and troubleshooting. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-Requisite Course: MDLS 5125 or approval of department head.

MDLS 5236. Medical Microbiology II Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion of antimicrobial susceptibility, anaerobic bacteria, mycobacteria, chlamydia, rickettsia, and an overview of infections by organ system. Emphasis is on epidemiology, pathogenesis, source of isolation, and conventional and molecular methods of diagnosis of human pathogenic organisms and high complexity analysis and troubleshooting. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-Requisite Course: MDLS 5137 or approval of department head.

MDLS 5244. Applications in Molecular Diagnostics I. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion of the theory and applications of molecular testing in microbiology, immunology, and pharmacogenomics. Methods discussed to include quantitative analysis, qualitative analysis, and methods of genotypic characterization.

MDLS 5245. Applications in Molecular Diagnostics II. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion of the theory and applications of molecular testing in oncology and genetics. Topics to include diagnosis of leukemia/lymphomas, solid tumors, hereditary cancer syndromes, and other genetic disorders.

MDLS 5246. Immunohematology II Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion of the principles of immunohematology in relation to transfusion and transplant medicine, donor processing, and component preparation and storage and high complexity analysis and troubleshooting. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-Requisite Course: MDLS 5147.

MDLS 5272. Clinical Laboratory Administration. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Principles and practices of administration of the clinical laboratory. Emphasis is placed on administrative issues unique to the clinical laboratory including coding, billing, reimbursement, government regulation, accreditation and information management processes. Prerequisite: MDLS 5206.

MDLS 5278. Clinical Chemistry II Lecture. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Discussion and comparison of diagnostic methods employed in the clinical chemistry laboratory. Emphasis is placed on diagnostic metabolites, enzymology, endocrinology, tumor markers and high complexity analysis and troubleshooting. Normal physiology and biochemical manifestations of disease are discussed. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program. Co-Requisite Course: MDLS 5179.

MDLS 5295. Clinical Cytogenetics Pract I. 2 Credit Hours (Lecture: 0 Hours, Lab: 13 Hours).

Under the supervision and instruction of a clinical instructor in a hospital or reference laboratory setting, the student will have the opportunity to expand their knowledge of principles and techniques involved in the practice of cytogenetics that were introduced in the diadactic portion of the curriculum. the student will gain experience in procedures related to karyotyping with an emphasis on peripheral blood specimens. Clinical correlations of the chromosomal findings are emphasized. Field assignment fee $75. Grading in this course is satisfactory or unsatisfactory.

MDLS 5296. Clinical Cytogenetics Pract II. 2 Credit Hours (Lecture: 0 Hours, Lab: 13 Hours).

Under the supervision and instruction of a clinical instructor in a hospital or reference laboratory setting, the student will have the opportunity to expand their knowledge of principles and techniques involved in the practice of cytogenetics that were introduced in the diadactic portion of the curriculum. The student will gain experience in procedures related to karyotyping with an emphasis on amniotic fluid, chorionic villi samples,bone marrow and solid tumor specimens. Clinical correlations of the chromosomal findings are emphasized. Field assignment fee $75. Grading in this course is satisfactory or unsatisfactory.

MDLS 5297. Clinical Cytogenetics Pract III. 2 Credit Hours (Lecture: 0 Hours, Lab: 13 Hours).

Under the supervision and instruction of a clinical instructor in a hospital or reference laboratory setting, the student will have the opportunity to expand their knowledge of principles and techniques involved in the practice of cytogenetics that were introduced in the diadactic portion of the curriculum. The student will gain experience in procedures related to karotyping, FISH and molecular techniques. Clinical correlations of the chromosomal findings are emphasized. Field assignment fee $75. Grading in this course is satisfactory or unsatisfactory.

MDLS 5298. Statistical Methods for Healthcare Research. 2 Credit Hours (Lecture: 2 Hours, Lab: 0 Hours).

Practical applications of general principles of descriptive and inferential statistics used in health care research. Skill development in use of statistical software as a tool to analyze health data available from national databases. Emphasis will be placed on the interpretation and communication of research results.

MDLS 5325. Clinical Molecular Microbiology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Studies of the genetics and physiology of microbes, including fundamental processes of gene regulation, genome structure, and protein synthesis and processing. Emphasis is placed on the clinical molecular identification of bacteria, viral, fungal and parasitic organisms including real-time PCR techniques, quality assurance practices, and interpretation of results in a clinical setting.

MDLS 5330. Medical Biochemistry. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

A review of the major biochemical processes in the human body, their physiology role and their relationship to human disease. Emphasis will be placed upon emerging diagnostic testing and clinical correlations in the areas of endocrinology, tumor biology, lipoprotine structure and function, diabetes case management, protein structure and function, and toxicology. Prerequisite: Students must be admitted into the Medical Laboratory Sciences Master of Science program.

MDLS 5331. Molecular and Cellular Pathology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

A study of the molecular and cellular aspects of human disease. Emphasis will be placed on microarrays and other emerging diagnostic testing as applied to the regulation of the eukaryotic cell cycle, signal transduction pathways, molecular mechanisms, receptor/membrane function and their relationship to tumor biology, endocrine dysfunction, dyslipidemia and other pathophysiologic conditions. Prerequisites: BIOL 5309 or MDLS 5202.

MDLS 5340. Clinical and Anatomic Pathology. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Clinical and anatomic pathology is focused on the development of pathophysiologic mechanisms underlying human disease. Students are introduced to basic etiologies and pathogenesis that underlie all diseases. More detailed discussions of pathologic mechanisms including structural lesions (morphology) and functional consequences (clinical presentation) will be discussed within specific diseases of organ systems. Applications of the clinical laboratory in disease diagnosis and management will also be included.

MDLS 5355. Clinical Cytogenetics Techniques I. 3 Credit Hours (Lecture: 1 Hour, Lab: 6 Hours).

This course introduces all aspects of the modern cytogenetics laboratory including karotyping and probe based assays including fluoresence in-situ hybridization (FISH). Quality assurance aspects of quality laboratory practices are introduced as well as regulatory issues. Course Fee $30 Lab Fee $30.

MDLS 5356. Clinical Cytogenetics Techniques II. 3 Credit Hours (Lecture: 1 Hour, Lab: 6 Hours).

This course is a continuation of MLS 5355 and provides more advanced practice in all aspects of the modern cytogenetics laboratory including karotyping and fluoresence in-situ hybridization (FISH). Quality assurance aspects of quality laboratory practices are emphasized as well as regulatory issues. Lab fee $2.

MDLS 5398. Statistical Methods Health Care Research. 3 Credit Hours (Lecture: 3 Hours, Lab: 0 Hours).

Practical applications of general principles of descriptive and inferential statistics used in health care research. Skill development in use of statistical software as a tool to analyze health data available from national databases. Emphasis will be placed on the interpretation and communication of research results. Course Fee $50.

MDLS 5412. Clinical Cytogenetics. 4 Credit Hours (Lecture: 4 Hours, Lab: 0 Hours).

This covers the history of cytogenetics, mechanisms of structural abnormalities, clinical correlation of autosomal and sex chromosome anomalies, cytogenetic syndromes, inheritance patterns and cancer genetics with a focus on correlation between the diagnosis and treatment of diseases associated with genetic abnormalities. Course Fee $30.

MDLS 5450. Molecular Diagnostics Techniques I. 4 Credit Hours (Lecture: 1 Hour, Lab: 9 Hours).

This course provides an introduction to the basic genetic techniques used in a clinical molecular genetics laboratory. Laboratory technique instruction, skill development and practice in isolation of DNA and RNA from clinical samples, preparation of nucleic acid probes, molecular hybridization techniques, amplification techniques and hybridization analysis will be addressed. Emphasis will be placed on laboratory design issues, prevention of product contamination, quality assurance and regulatory issues, safety, and interpretation and application of test results.

MDLS 5451. Molecular Diagnostics Techniques II. 4 Credit Hours (Lecture: 1 Hour, Lab: 9 Hours).

This course provides a continuation of the basic genetic techniques covered in Molecular Diagnostics Techniques I, which may be used in a clinical molecular genetics laboratory. Laboratory technique instruction, skill development and practice in real-time PCR, reverse transcriptase PCR, nested PCR and single nucleotide polymorphism (SNP) detection will be emphasized. Emphasis will be placed on laboratory design issues, prevention of product contamination, quality assurance and regulatory issues, safety, and interpretation and application of test results. Prerequisite: MDLS 5450.